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박해용 ( Park Hae-Yong ) - 국민건강보험공단 일산병원 연구분석팀
윤지선 ( Yoon Ji-Sun ) - 국민건강보험공단 일산병원 산부인과
백혜원 ( Baek Hae-Won ) - 연세대학교 의과대학 산부인과학교실
정재은 ( Chung Jae-Eun ) - 국민건강보험공단 일산병원 산부인과
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Abstract
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Purpose: This study aims to investigate the effects of smoking on the development of placenta-associated syndromes, including preeclampsia, abruptio placentae, and placenta previa, which share the common pathophysiology of vascular compromise of the placenta.
Methods: A total of 966,629 pregnancies identified from the Korean National Insurance Claims Database and the National Health Information Database were analyzed from 2010 to 2014. The adjusted odds ratio and attributable risk of smoking for the development of placenta-associated syndromes, such as preeclampsia, placenta previa, and abruptio placentae, were analyzed. Maternal age, alcohol consumption, exercise habit, and economic status were controlled as confounding variables. A binary logistic regression model was used, and simple and multiple logistic regression analyses were performed.
Results: Among 966,629 pregnancies, 11.86% of women were ever smokers. Ever smokers had a higher risk of developing placenta previa (adjusted odds ratio, 1.23; 95% confidence interval [CI], 1.18?1.29; adjusted attributable risk, 18.70%). The adjusted odds ratio of developing placenta-associated syndromes in ever smokers compared to nonsmokers over the age of 35 years with a low economic status was 1.32 (95% CI, 1.18?1.47), with an adjusted attributable risk of 23.95%.
Conclusion: The risk of developing placenta-associated syndromes, such as preeclampsia, placenta previa, and abruptio placentae, is high in ever smokers. Pregnant ever smokers who are >35 years and belong to the lower one-third of the economic division require special care to prevent the development of placentaassociated syndromes.
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KeyWords
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Smoking exposure, Placenta-associated syndrome, Placenta vascular compromise
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원문 및 링크아웃 정보
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등재저널 정보
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